New studies given researchers an unprecedented insight into the neural basis for effects produced by one of the most powerful drugs ever created. One study could pave the way for LSD or related chemicals to be used to treat psychiatric disorders. Researchers suggest the drug could pull the brain out of thought patterns seen in depression and addiction through its effects on brain networks.

Amanda Feilding, director of the Beckley Foundation that helped fund the study said, said: “We are finally unveiling the brain mechanisms underlying the potential of LSD, not only to heal but also to deepen our understanding of consciousness itself.”  A study appearing in the journal Proceedings of the National Academy of Sciences reveals how LSD reverses the more restricted thinking we develop from infancy to adulthood.

An Oxford philosopher thinks he can distill all morality into a formula. Is he right?

The philosopher Derek Parfit believes that neither of the people is you, but that this doesn’t matter. It doesn’t matter that you have ceased to exist, because what has happened to you is quite unlike ordinary death: in your relationship to the two new people there is everything that matters in ordinary survival—a continuity of memories and dispositions that will decay and change as they usually do. Most of us care about our future because it is ours—but this most fundamental human instinct is based on a mistake, Parfit believes. Personal identity is not what matters.

It's a terrifying fact: More than 47,000 people in America died of drug overdoses in 2014 — in what's been widely called an epidemic. But the biggest killer of this epidemic isn't cocaine, meth, or even heroin; it's totally legal opioid painkillers. Here's how it happened:

Since the 1990s, doctors have been under more and more pressure to treat pain as a serious medical issue. Pharmaceutical companies took advantage of this desire, marketing opioid painkillers like OxyContin and Vicodin as a safe, effective solution to pain.

In a culture in which it’s customary to eat three large meals a day while snacking from morning to midnight, the idea of regularly skipping meals may sound extreme. But in recent years intermittent fasting has been gaining popular attention and scientific endorsement. But some are now looking at the practice as a source of health and longevity.

 
Predestination is a bit of a thorny thicket for theologians.  Today, strict predestinarianism (to include double predestination) is a minority view.  Among the broad theological community, predestination is widely understood to be heresy. Why?

As this paper will illustrate, that free will does not exist (the premise of strict predestination) is simply not supported in scripture and in many places directly contradicts scripture.  Then there is the notion of paradox.

A computing legend has died. The inventor of email, Ray Tomlinson, suffered an apparent heart attack on Saturday, according to reports. He was 74 years old.

Tomlinson sent the very first email back in 1971; at the time, he was working in Boston at Bolt, Beranek, and Newman (BBN), a company that was instrumental in the development of a very early version of the internet, called ARPANET. As an employee, he was "looking for problems [ARPANET] could solve," Tomlinson said in a 2012 interview.

Buddhist monks from around the world gathered at Thailand's ancient Ayutthaya city on Thursday for the last day of the International Buddhist Confederation (IBC) during which they laid emphasis on actions to tackle climate change.

The delegates from 320 organisations in 39 countries, including the United States, the United Kingdom, Germany, Mexico and Brazil, participated in the second gathering of the IBC. One of the key issues discussed were how the monks in different countries find ways to address the climate change.

"Half of Earth's surface and seas must be dedicated to the conservation of nature, or humanity will have no future."

Unstanched haemorrhaging has only one end in all biological systems: death for an organism, extinction for a species. Researchers who study the trajectory of biodiversityloss are alarmed that, within the century, an exponentially rising extinction rate might easily wipe out most of the species still surviving at the present time.

David Bowie has died after a battle with cancer, his rep confirmed to Billboard. He was 69. "David Bowie died peacefully today surrounded by his family after a courageous 18 month battle with cancer. While many of you will share in this loss, we ask that you respect the family’s privacy during their time of grief," read a statement posted on the artist's official social media accounts. 

The influential singer-songwriter and producer excelled at glam rock, art rock, soul, hard rock, dance pop, punk and electronica during his eclectic 40-plus-year career. He just released his 25th album, Blackstar, Jan. 8, which was his birthday. His artistic breakthrough came with 1972’s The Rise and Fall of Ziggy Stardust and the Spiders From Mars, an album that fostered the notion of rock star as space alien. Fusing British mod with Japanese kabuki styles and rock with theater, Bowie created the flamboyant, androgynous alter ego Ziggy Stardust.

The Iranian foreign minister on Monday reacted to an open letter to Iran’s leaders by 47 U.S. Republican senators who had warned Tehran that any nuclear deal that the Islamic Republic signs with President Barack Obama’s administration won’t last after Obama leaves office. Mohammad Javad Zarif said the letter lacks “legal validity” and shows that the signatories of the letter are “ignorant of international law”. “In our view this letter has no legal validity and is just a propaganda scheme,” Zarif noted. The letter proved that “like” Israeli Prime Minister Benjamin Netanyahu these senators “are opposed to any deal”.

At the time that the ruling was delivered, Kennedy’s faith that access and influence would not corrupt the system was exceeded in curiousness only by his belief that the American people would feel similarly. But as the years have passed, and as studies showing the U.S. to be a donor-run system akin to oligarchy have gone mainstream, his declaration has begun to make a bit more sense. Just so long as “the electorate” is defined as the lobbying industry and its clients, his prediction looks downright clairvoyant.

Successful companies frequently rely heavily on just one product for the majority of their sales and profit. Because each product represents such an outsized share of their respective company’s revenue, the products’ tremendous margins are the foundation of the company’s profit.  The most profitable products tend to rely on the power of their brand, which can command a premium price and sell extraordinary numbers of units.

What are the most profitable?  And why...

Facebook has announced that it’s teaming up with four of the world’s largest corporate data brokers to “enhance” the ad experience for users. Datalogix, Epsilon, Acxiom, and BlueKai obtain information gathered about users through online means (such as through cookies when users surf the web) as well as through offline means (such as through loyalty cards at supermarkets and product warranty cards).

After many years of professional consulting — serving stakeholders from the server room to the board room — I moved into management and encountered fresh perspective.

I learned things that I wished someone had told me early in my career. I became a stakeholder and ate the proverbial dogfood. And along the way, I learned things that are worth sharing. I hope these “secrets” resonate with someone (as I believe they would have resonated with me 20 years ago).

Scientists at the European Organization for Nuclear Research, known as CERN, announced yesterday that they’re even more certain than they were last summer (like, more than 99.999999999 percent sure) that they've seen a Higgs boson particle—even if it’s not the Higgs boson particle. Why does it even matter?

Significant flaws in Microsoft Operating Systems and programs are becoming a smaller portion of the total. Secunia reports that 86 percent of active vulnerabilities in 2012 affected third-party products such as Java, Flash and Adobe Reader. In 2007, third-party vulnerabilities made up less than 60 percent of the total.